Best sedating anti depressant

Side effects: Jitteriness, insomnia, headaches, dry mouth, nausea (and, rarely, risk of seizure).

Whom it may be suitable for: Not an ideal first-line treatment: Start-up can be difficult to tolerate, and serotonin is often needed to effect mood change.

There are a number of antidepressants available that work in slightly different ways and have different side effects.

Whom it may be suitable for: Depression sufferers whose symptoms include fatigue.

Side effects: Sedation, fatigue, dry mouth, constipation, increased appetite, weight gain.

Whom it may be suitable for: Depression sufferers with anxiety and insomnia: It’s the most sedating antidepressant.

Other common side effects: headache, dry mouth, constipation, sweating, dizziness, sexual dysfunction.

Whom it may be suitable for: Depression sufferers with fatigue-like symptoms (norepinephrine works on the adrenal system); also a good option when SSRIs don’t work; not ideal for patients with hypertension.

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