Best sedating anti depressant
Side effects: Jitteriness, insomnia, headaches, dry mouth, nausea (and, rarely, risk of seizure).
Whom it may be suitable for: Not an ideal first-line treatment: Start-up can be difficult to tolerate, and serotonin is often needed to effect mood change.
There are a number of antidepressants available that work in slightly different ways and have different side effects.
Whom it may be suitable for: Depression sufferers whose symptoms include fatigue.
Side effects: Sedation, fatigue, dry mouth, constipation, increased appetite, weight gain.
Whom it may be suitable for: Depression sufferers with anxiety and insomnia: It’s the most sedating antidepressant.
Other common side effects: headache, dry mouth, constipation, sweating, dizziness, sexual dysfunction.
Whom it may be suitable for: Depression sufferers with fatigue-like symptoms (norepinephrine works on the adrenal system); also a good option when SSRIs don’t work; not ideal for patients with hypertension.